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  • I. Tissue Structure
  • Membrane Structure
  • Tissue Internal Structure
  • Collagen is the basic structural protein
    that organizes internal frame and
    membrane of the tissue and organ.
  • Cartilage
  • Wound
  • Bone
  • Soft Tissue
  • II. Guided Tissue
  • After 2 weeks in collagen
  • After 2 weeks in collagen gel
  • BioCollagen scaffold provides cell
    migration, cell attachment and
  • III. Cell (MSC) Vitalization
  • Collagen-MSC interaction
    (0 day)
  • Collagen-MSC interaction
    (3 weeks)
  • Cell proliferation and differentiation are enhanced by Collagen-MSC
    interaction (CMI).
  • IV. Growth Factor Release
  • VEGF Release
  • Angiogenesis
  • BioCollagen activates platelets optimally and consistently for
    releasing growth factors (VEGF, ect.) and inducing angiogenesis.

Tissue Healing Mechanism & BioCollagen

Collagen is a basic structural protein comprising almost 30% of human tissue. In the bone, collagen is 30% of dry weight. The ligament, tendon and cartilage have ranged from 60% to 75% of dry weight. In the dermis, collagen is up to 56% to 70% of the tissue.

  • The accumulation of collagen in the repair domain is an absolute and indispensable condition for successful tissue regeneration. Without collagen, the healing deficiency would be expected. BioCollagen is a ubiquitous biomolecule with the valuable characteristics: organizing tissue structure, guided tissue regeneration, cell (MSC) vitalization, releasing growth factors, atelocollagen, high purity, aseptic product and advanced structure.
  • RMS BioCollagen is ‘the biocompatible atelocollagen?with the least immunogenicity due to a genuine triple-helix structure with the removal of antigen at the terminal telopeptide. BioCollagen leads vital role as an extracellular matrix cues for tissue regeneration mechanism through CMI (collagen-MSC interaction).
    * Difference of Hydrolyzed Collagen, Gelatin, Acellular Matrix, DBM: Non-purified, No intact triple helix, Inadequate removal of antigenicity.