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CARTIFILL - Cartilage Cell Scaffold

CartiFill™ is cartilage cell scaffold for advanced technique of microfracture. Microfracture procedures have been widely used to treat cartilage defects by withdrawing stem cells from bone marrow. However, the results are not consistent than expected due to unstable cell recruitment. CartiFill™ creates stable matrix structure of cell scaffold in the cartilage defects after microfracture with finely purified BioCollagen and fibrin glue.

Cartilage Cell Scaffold

  • Advanced microfracture
  • Secured stem cell chondrogenesis
  • Reconstruction of tissue structure
Application: Cartilage Defects

Composition

CartiFill™: BioCollagen 3cc in syringe
Accessory Unit

How to use

(1) CartiFill™ is implanted with fibrin glue for gel-type scaffold.
(2) Gel-type CartiFill™ is easily implanted after microfracture.

APPLICATION

Cartilage Defects, Knee Joint

Cartilage Defects, Ankle Joint

REFERENCES
  • 1. Furukawa, T., et al., Biochemical studies on repair cartilage resurfacing experimental defect in the rabbit knee.
    J Bone Joint Surg Am, 1980. 62: p. 79-89.
  • 2. Lee, J.K., et al., Efficacy of atelocollagen and fibrin glue mixture on articular cartilage defect of rabbit. Journal of
    RegenPlasty, 2012. 48: p. 10-16.
  • 3. Rudert, M., Histological evaluation of osteochondral defects: Consideration of animal models with emphasis on the rabbit,
    experimental setup, follow-up and applied methods. Cells Tissues Organs, 2002. 171: p. 229-40.
  • 4. Shetty, A.A., et al., Autologous collagen-induced chondrogenesis: single-stage arthroscopic cartilage repair technique.
    Orthope dics, 2013. 36(5): p. 648-52.
  • 5. Stelzeneder, D., et al., Repair tissue quality after arthroscopic autologous collagen-induced chondrogenesis (ACIC) assessed
    via T2* mapping. Skeletal Radiol, 2013. 42(12): p. 1657-64.
  • 6. Volpi, P., et al., Autologous collagen-induced chondrogenesis technique (ACIC) for the treatment of chondral lesions of the
    talus. Knee Surg Sports Traumatol Arthrosc, 2014. p. 1-7.

ADVANTAGES

  • CartiFill™
    • Cell guarding effects: secures migrated cells
    • Easy to recreate the 3D structure of cartilage
    • Simple fitting to variable cartilage defects
  • Microfracture
    • Withdraw bone marrow stem cells
    • Stem cell flows down to joint space and
      synovial fluid
    • Inadequate amount and unsatisfactory quality
      of fibrocartilage

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