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OSSFILL - Dynamic Guided Bone Regeneration (GBR)

OssFill™ is biomimetic bone supplement with finely purified atelocollagen and hydroxyapatite. Bone is a mineralized collagenmatrix;
if the mineral components are dissolved out of bone, it becomes rubbery collagen matrix. Implanted OssFill™ closely resembles developed osteoid tissue during bone repair stage. OssFill™ leads to dynamic guided bone regeneration (GBR) by roviding cell pathway for bone ingrowth and enhancing valid cell activation and vascularization.

Dynamic Guided Bone Regeneration (GBR)

  • Natural Biomimetic Bone Supplement
  • BioCollagen with Inorganic Materials
  • Active Cell Pathway for Bone Ingrowth
Application: Spinal fusion, Bone defects, Fracture healing, Non-union,Augmentation for HTO (High Tibial Osteotomy)


OssFill™: Hydroxyapatite + BioCollagen (1cc, 3cc, 6cc)

How to use

OssFill™ can be implanted with stem cell, autograft, biomaterials and other bone supplements.


Spinal Fusion

Spinal Fusion
Osteotomy Healing

Fracture Healing

Dental Augmentation

  • 1. Jang, J.D., et al., Accelerate bone healing using atelocollagen-based solution containing bone marrow-derived mononuclear
    cells (ASTEM-B) in animal bone defect model. Tissue Engineering and Regenerative Medicine, 2008. 5(4-6): p. 939-44.
  • 2. Kagawa, R., et al., Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix.
    J Bone Miner Metab, 2012. 30(6):p. 638-50.
  • 3. Kikuchi, M., Hydroxyapatite/collagen bone-like nanocomposite. Biol Pharm Bull, 2013. 36(11): p. 1666–9.
  • 4. Lee, J.K., et al., Osteogenicity of atelocollagen and hydroxyapatite in the defected rabbit bone. Journal of RegenPlasty,
    2013. 51: p. 32-8.
  • 5. Qian, Y., et al., Natural bone collagen scaffold combined with autologous enriched bone marrow cells for induction of
    osteogen esis in an ovine spinal fusion model. Tissue Engineering: Part A, 2009. 15(11): p. 3547-58.
  • 6. Suh, D.S., et al., Application of regenerative medicine in bone grafts. Journal of RegenPlasty, 2013. 52(3): p. 52-9.
  • 7. Yang, X.B., et al., Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Engineering,
    2004. (7-8): p. 1148-59.


  • OssFill™
  • Inorganic Bone Substitute
  • Allograft (DBM)
    • Mimics the natural bone molecules
    • Biocompatible atelocollagen
    • Ideal collagen-MSC (cell) interaction
    • Dynamic guided bone regeneration
    • Active cell pathway for ingrowth
    • No risk of disease transmission
    • No contaminants and no impurities
    • Only inorganic molecules of bone
    • No collagen supplement
    • Weak cell interaction
    • weak guided bone regeneration
    • Weak cell pathway for ingrowth
    • No risk of disease transmission
    • Possible production of hamful substance
    • Denatured molecules of bone
    • Imperfect collagen fragment (DBM)
    • Weak cell interaction
    • Incomplete guided bone regeneration
    • Weak cell pathway for ingrowth
    • Possible risks of disease transmission
    • Possible risks of impurities